Mucor circinelloides Growth and Differentiation in the Fungus A Subunit of Protein Kinase A Regulates
نویسندگان
چکیده
منابع مشابه
A subunit of protein kinase a regulates growth and differentiation in the fungus Mucor circinelloides.
The cyclic AMP (cAMP)-dependent protein kinase A (PKA) signaling pathway plays a role in regulating development, growth, and virulence in a number of fungi. To determine whether PKA plays a similar function in zygomycete fungi, a mutant of Mucor circinelloides was generated that lacks pkaR1, one of the regulatory subunits of PKA. The mutant showed a reduction in growth and alterations in germin...
متن کاملProtein kinase A regulatory subunit isoforms regulate growth and differentiation in Mucor circinelloides: essential role of PKAR4.
The protein kinase A (PKA) signaling pathway plays a role in regulating growth and differentiation in the dimorphic fungus Mucor circinelloides. PKA holoenzyme is comprised of two catalytic (C) and two regulatory (R) subunits. In M. circinelloides, four genes encode the PKAR1, PKAR2, PKAR3, and PKAR4 isoforms of R subunits. We have constructed null mutants and demonstrate that each isoform has ...
متن کاملThe biosorption of Congo red azo dye by fungus Mucor circinelloides and its application in the decolorization of textile industry wastewater
The extensive application of dyes in the textile industries and their discharge in the wastewaters leads to numerous environmental pollutions; therefore, treating these wastewaters by efficient and eco-friendly methods is a necessity. In this study, potent strains were isolated by the enrichment technique according to their maximum dye sorption at the lowest possible time at 500nm. Consequently...
متن کاملPKA from Mucor circinelloides: model to study the role of linker I in the interaction between R and C subunits.
Protein kinase A from the fungus Mucor circinelloides shows high affinity interaction between regulatory (R) and catalytic (C) subunits. Its R subunit shows a differential presence of several acidic residues in linker I region, in the amino terminus. Mutants R1, lacking the N-terminal region, and R2, lacking the acidic cluster, were used to analyze its effect on the interaction with the C subun...
متن کاملProtein kinase A is involved in the control of morphology and branching during aerobic growth of Mucor circinelloides.
The cAMP signal transduction pathway controls many processes in fungi. The Mucor circinelloides pkaR and pkaC genes, encoding the regulatory (PKAR) and catalytic (PKAC) subunit of the cAMP-dependent protein kinase A (PKA), have been cloned recently. Expression analysis during the dimorphic shift and colony morphology suggested a role for PKAR in the control of morphology and branching. Here str...
متن کامل